Article in Japanese

A case of norovirus infection with acute encephalopathy and septic shock

Nachika IKEDA¹⁾, Shinji KAWABE²⁾, Kenta ITO¹⁾

A previously healthy 11-year-old boy developed acute encephalopathy and septic shock through a norovirus infection. On the day of symptom onset, he developed fever and drowsiness. He was admitted subsequently to his previous hospital. On day 2, he was transferred to the Pediatric Intensive Care Unit of Aichi Children's Health and Medical Center because of vomiting, diarrhea, hypotension, and exacerbation of impaired consciousness. Results of the immunochromatographic test for the rapid detection of norovirus and bacterial cultures of his blood and cerebrospinal fluid were negative. An electroencephalogram showed diffuse high-amplitude slow waves (1～2 Hz) at the frontal region. On day 4, he was extubated, and inotropic agents were discontinued. On day 12, he was discharged from the hospital without any sequela. After discharge, polymerase chain reaction detected the GII-2 norovirus genome in his stool, which was submitted to the Public Health Center.

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1) Department of General Pediatrics, Aichi Children's Health and Medical Center
2) Department of Infection and Immunology, Aichi Children's Health and Medical Center

Key words	norovirus, acute encephalopathy, septic shock
Received	October 18, 2018
Accepted	February 26, 2019

31 (2)：157─162,2019