Article in Japanese
A case report of pediatric meningitis caused by Haemophilus influenzae type f with ftsI mutation
Haruki Mori1), Shota Yamamoto1), Taijiro Watanabe1), Taizo Kusano1), Noriko Takeuchi2), Misako Ohkusu2), Naruhiko Ishiwada2), Tadashi Hoshino1)
We report a case of pediatric meningitis caused by Haemophilus influenzae type f (Hif). A 1-year and 3-month-old girl was admitted to our hospital with a fever and convulsion. She was diagnosed with bacterial meningitis because CSF general examination showed elevated cell counts, and CSF smears showed Gram-negative coccobacilli. Multiplex PCR analysis of CSF was positive for H. influenzae, and it was also isolated from blood and CSF culture. Because an epidural abscess was suspected, the patient was treated with antimicrobial agents for a total of 4 weeks, but had hearing loss. The capsular type of H. influenzae identified as type f, and was found to be genotype β-lactamase non-producing ampicillin-resistant strain (gBLNAR) with ftsI mutation. This is a case of pediatric meningitis caused by gBLNAR-Hif, which is still rarely reported in Japan. It is essential to pay attention to the capsular type and genetic analysis of non-type b encapsulated strains of H. influenzae, and the trends in antibiotic resistance in the future.
1)Department of Infectious Diseases, Chiba Children’s Hospital
2)Division of Infectious Disease Control, Medical Mycology Research Center, Chiba University
Key words | Haemophilus influenzae type f, ftsI mutation, meningitis, ST124 |
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Received | March 1, 2024 |
Accepted | July 27, 2024 |
36 (3):265─271,2024
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