The Journal of Pediatric Infectious Diseases and lmmunology Online Journal

Abstract

The Journal of Pediatric Infectious Diseases and Immunology > Vol.36 No.3 contents > Abstract

Article in Japanese

Multisystem inflammatory syndrome in children with acute encephalopathy with biphasic seizures and reduced diffusion

Yui Yuda1), Masatoki Sato1), Mika Yamada1), Yuichiro Asano1), Maki Nodera1), Yuichi Suzuki1), Mitsuaki Hosoya1)

We report a case of multisystem inflammatory syndrome in children (MIS-C) with acute encephalopathy with biphasic seizures and reduced diffusion (AESD) after initial infection with or exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A 9-year-old girl presented with frequent vomiting and diarrhea on day 0 and a high fever on day 2. On day 2, she was transferred to our hospital for further treatment because of a decreased level of consciousness, signs of circulatory failure, and seizures. The blood test performed upon admission indicated an inflammatory response and multiple organ involvement. MIS-C was suspected due to severe gastrointestinal symptoms and close with a sibling diagnosed with coronavirus disease 2019 6 weeks prior. Immunoglobulin therapy and methylprednisolone pulse treatment were administered. On day 9, seizures recurred. Brain diffusion-weighted magnetic resonance imaging revealed high signal intensities in the cerebral cortex and bilateral hippocampus. MIS-C accompanied by AESD was diagnosed after obtaining a positive anti-SARS-CoV-2 N antibody test. This case demonstrates that severe cases of acute encephalopathy should also be noted in MIS-C.


1)Department of Pediatrics, Fukushima Medical University

Key words COVID-19, SARS-CoV-2, MIS-C, AESD
Received March 11, 2024
Accepted July 8, 2024

36 (3):257─265,2024

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