Article in Japanese

Acute tubulointerstitial nephritis after the third coronavirus disease vaccine dose: A case report

Akiyoshi HORIE^1）, Mayu SASAKI^1）, Miku NAKAMURA^1）, Shinichi HARANO^1）, Yuuji MORITOU^1）, Yuki HASEGAWA^1）, Takehisa FUJIWAKI^1）, Akiyoshi NARIAI^2）

We present the case of a 15-year-old adolescent admitted to the hospital for lowgrade fever, headache, and backache after being administered the third dose of the SARS-CoV-2 vaccine. Laboratory findings revealed acute kidney injury and renal biopsy-proven acute tubulointerstitial nephritis (ATIN). The patientʼs history and laboratory findings did not reveal any alternative etiologic factor. Therefore, vaccineassociated ATIN was considered most likely. Recent studies worldwide have reported SARS-CoV-2 vaccine-induced renal injury. However, mechanisms underlying the association between ATIN and the SARS-CoV-2 vaccine remain unconfirmed. Further reports will provide greater clarity regarding the possible adverse events associated with the SARS-CoV-2 vaccine. Also, clinicians should consider the possibility of vaccineinduced kidney injury in patients with minor symptoms.

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1）Division of Pediatrics, Matsue Red Cross Hospital
2）Division of Infectious Disease, Matsue Red Cross Hospital

Key words	Severe acute respiratory syndrome coronavirus 2, messenger RNA-based vaccine, acute tubulointerstitial nephritis, acute kidney injury
Received	December 28, 2022
Accepted	March 9, 2023

35 (2)：135─142,2023