Article in Japanese

Disseminated cryptococcosis presenting with fever and hypereosinophilia in an immunocompetent patient

Azusa MATSUBARA¹⁾, Masao TOGAWA¹⁾, Aya KITAGUCHI¹⁾, Kiyoko AMO¹⁾

Immunocompetent hosts with cryptococcosis are usually asymptomatic, and the associated pulmonary infections are often discovered as incidental findings. Here, a case of disseminated cryptococcosis, presenting with fever and hypereosinophilia is reported in a 15-year-old immunocompetent male patient admitted to this hospital. He had fever for 11 days, and showed leukocytosis, eosinophilia, and elevated inflammatory markers. Contrast CT scan at a previous hospital had revealed enlarged mediastinal and abdominal lymph nodes, presence of pulmonary nodules, and multiple nodules in the liver and spleen. Histopathology of tissue, obtained through endobronchial ultrasound-guided fine needle aspiration, revealed yeast cells. Cryptococcus neoformans was detected in the culture of this aspirated tissue. These observations suggest that if a patient shows sustained fever and eosinophilia, cryptococcosis should be suspected as a possibility.

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1) Department of Pediatric Emergency, Children's Medical Center, Osaka City General Hospital

Key words	Cryptoccoccus neoformans, disseminated cryptococcosis, eosinophilia, allergy
Received	February 10, 2020
Accepted	June 11, 2020

32 (3)：221─227,2020