The Journal of Pediatric Infectious Diseases and lmmunology Online Journal


The Journal of Pediatric Infectious Diseases and Immunology > Vol.32 No.3 contents > Abstract

Article in Japanese

Disseminated cryptococcosis presenting with fever and hypereosinophilia in an immunocompetent patient

Azusa MATSUBARA1), Masao TOGAWA1), Aya KITAGUCHI1), Kiyoko AMO1)

Immunocompetent hosts with cryptococcosis are usually asymptomatic, and the associated pulmonary infections are often discovered as incidental findings. Here, a case of disseminated cryptococcosis, presenting with fever and hypereosinophilia is reported in a 15-year-old immunocompetent male patient admitted to this hospital. He had fever for 11 days, and showed leukocytosis, eosinophilia, and elevated inflammatory markers. Contrast CT scan at a previous hospital had revealed enlarged mediastinal and abdominal lymph nodes, presence of pulmonary nodules, and multiple nodules in the liver and spleen. Histopathology of tissue, obtained through endobronchial ultrasound-guided fine needle aspiration, revealed yeast cells. Cryptococcus neoformans was detected in the culture of this aspirated tissue. These observations suggest that if a patient shows sustained fever and eosinophilia, cryptococcosis should be suspected as a possibility.

1) Department of Pediatric Emergency, Children's Medical Center, Osaka City General Hospital

Key words Cryptoccoccus neoformans, disseminated cryptococcosis, eosinophilia, allergy
Received February 10, 2020
Accepted June 11, 2020

32 (3):221─227,2020