Article in Japanese
Disseminated cryptococcosis presenting with fever and hypereosinophilia in an immunocompetent patient
Azusa MATSUBARA1), Masao TOGAWA1), Aya KITAGUCHI1), Kiyoko AMO1)
Immunocompetent hosts with cryptococcosis are usually asymptomatic, and the associated pulmonary infections are often discovered as incidental findings. Here, a case of disseminated cryptococcosis, presenting with fever and hypereosinophilia is reported in a 15-year-old immunocompetent male patient admitted to this hospital. He had fever for 11 days, and showed leukocytosis, eosinophilia, and elevated inflammatory markers. Contrast CT scan at a previous hospital had revealed enlarged mediastinal and abdominal lymph nodes, presence of pulmonary nodules, and multiple nodules in the liver and spleen. Histopathology of tissue, obtained through endobronchial ultrasound-guided fine needle aspiration, revealed yeast cells. Cryptococcus neoformans was detected in the culture of this aspirated tissue. These observations suggest that if a patient shows sustained fever and eosinophilia, cryptococcosis should be suspected as a possibility.
1) Department of Pediatric Emergency, Children's Medical Center, Osaka City General Hospital
|Key words||Cryptoccoccus neoformans, disseminated cryptococcosis, eosinophilia, allergy|
|Received||February 10, 2020|
|Accepted||June 11, 2020|