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Article in Japanese

Diversity of clinical characteristics of facial nerve palsy concomitant with Epstein-Barr virus and Cytomegalovirus infection

Tadafumi YOKOYAMA1), Yuta TAKEMURA1), Eiko KOIZUMI1), Asumi JINKAWA1), Mari YAMAMIYA1), Misato OBATA1), Kengo MIYASHITA1), Mika INOUE1), Shinobu SAKAZUME1), Kazuhide OHTA1)

Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are causative pathogens of infectious mononucleosis (IM). Although it is relatively rare, IM is known to be one of the causes of facial nerve palsy (FNP). However, the pathogenesis is unclear in how EBV and CMV make FNP.
This study accumulated and reviewed past literature in order to clarify the clinical characteristics of FNP with EBV and CMV infection.
It was found that FNP patients with acute otitis media, caused by EBV, showed characteristics like those in infancy, with IM symptoms, unilateral palsy, and FNP that developed 1 to 2 days after proceeding cold symptoms. On the other hand, adult FNP patients with another neurological symptom showed fewer IM symptoms, and bilateral palsy that developed 1 to 2 weeks after proceeding symptoms. FNP in patients due to CMV tends to be a manifestation of Gullain-Barré syndrome.
In conclusion, the clinical characteristics of FNP with EBV and CMV infection were clarified and are apparently different according to the virus, age and concomitant symptoms such as IM, acute otitis media and another neurological symptom.

1) Department of Pediatrics, National Hospital Organization Kanazawa Medical Center

Key words facial nerve palsy, Epstein-Barr virus, cytomegalovirus, infectious mononucleosis, acute otitis media
Received January 23, 2020
Accepted June 13, 2020

32 (3):187─194,2020