Article in Japanese

The examination of antifungal agents in pediatric fungemia in Kurume University Hospital

Mizuki IDE¹⁾, Kenji GOTOH¹⁾, Atsushi MIYAKE¹⁾, Kiyohito OKUMIYA¹⁾, Kazuaki TATARA¹⁾, Yosuke NAKASHIMA¹⁾, Mariko TERAMACHI¹⁾, Yuhei TANAKA¹⁾, Yushiro YAMASHITA¹⁾

The purpose of this study was to reveal the characteristics of fungemia in the pediatric ward of Kurume University Hospital. This study retrospectively investigated medical and microbiological records of eight cases of fungemia isolated between April 2014 and March 2016 at the Hospital. Fungi were detected in three cases of Candida albicans, two of Trichosporon asahii, and one case of each Candida parapsilosis, Cryptococcus laurentii, and Rhodotorula sp.. All eight cases had underlysing disease, with three cases having extremely low birth weight, two having congenital heart diseases, two with malignant diseases and one who had endocrine disease. All of the cases had central venous catheter, which was thought to be high risk of fungemia. This study found 5 yeasts that had high minimal inhibitory concentrations (MICs) to fluconazole or micafungin (MCFG). Therefore, monitoring antifungal agent sensitivity should be continued. Two cases of T. asahii, which had extremely low birth weight, used corticosteroid, and fungemia broke through during prophylactic administration of MCFG at birth. When considering this result, Liposomal Amphotericin B might be used for invasive fungal infection.

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1) Department of Pediatrics and Child Health, Kurume University School of Medicine

Key words	fungemia, anti-fungal agents, drug susceptibility, children
Received	February 7, 2019
Accepted	June 4, 2019

31 (3)：241─245,2019