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Article in Japanese

A pediatric case of recurrent pneumococcal bacteremia by non-vaccine serotype after administration of 13-valent pneumococcal conjugate vaccines

Kentaro KATO1), Atsuko HATA1), Takakazu YOSHIOKA1), Daisuke HATA1)

Vaccinations with 13-valent pneumococcal conjugate vaccines (PCV13) have decreased the incidence of invasive pneumococcal disease (IPD), but increased that of non-vaccine serotype (NVST) disease. This report describes the case of a girl who had recurrent bacteremia from NVST-Streptococcus pneumoniae at the ages of 14, 16, 26, and 48 months after 3 doses of PCV13 administration. No anatomic abnormality was detected. Screening tests for primary immunodeficiency gave results within the normal range for her age. S. pneumoniae persists as a causal agent of severe bacterial infectious diseases. Treatment of IPD must be started as soon as possible for patients with various severities. Moreover, extremely effective tools are required, such as next-generation vaccines targeting pneumococcal common antigens.

1) Department of Pediatrics, Kitano Hospital, Tazuke Kofukai Medical Research Institute

Key words Streptcoccus pneumoniae, 13-valent pneumococcal conjugate vaccine (PCV13), capsular serotype, nontypable, invasive pneumococcal disease (IPD)
Received September 20, 2018
Accepted February 12, 2019

31 (2):137─142,2019