Article in Japanese

Clinical study of 79 patients of pertussis in children from 2012 to 2017

Toshihiko MORI¹⁾, Emiko HOSHINO¹⁾, Satoshi HIRAKAWA¹⁾, Yuki KUROIWA¹⁾

This study evaluated 79 children with pertussis between January 2012 and December 2017. Laboratory diagnosis of pertussis found 17 patients positive by culture, one patient positive by the LAMP method, and 61 patients diagnosed from serological tests. Sixteen patients were diagnosed with an increase of more than two-fold in anti-PT-IgG antibody in acute and convalescent pair sera; 3 were diagnosed with Bordetella pertussis IgM/IgA antibody positive; one unvaccinated patient was diagnosed with positive anti-PT-IgG antibody; and 41 patients were diagnosed with anti-PT-IgG≥100 EU/mL in single serum. Sixteen patients (20%) were unvaccinated. All 15 patients aged under 1 year were less than 6 months old. Two of them had received single inoculation for diphtheria, tetanus, and acellular pertussis, and an inactivated polio vaccine (DTP-IPV). The remaining 13 patients had not been vaccinated. Eleven of them were less than 3 months old, and had not reached the current vaccination age. Forty nine patients of 60 patients over 4 years old had been vaccinated, and only one patient had not been vaccinated. At present in Japan, diphtheria and tetanus toxoids are inoculated in children aged between 11 and 12 years, but this should be changed to a schedule including acellular pertussis vaccine as soon as possible. In addition, a change in the starting age of DPT-IPV from the current 3 months to 2 months should be considered.

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1) Department of Pediatrics, NTT East Sapporo Hospital

Key words	children, pertussis, serological tests, anti-PT-IgG antibody, Bordetella pertussis IgM/IgA antibody
Received	May 21, 2018
Accepted	February 14, 2019

31 (2)：103─110,2019