Article in Japanese

Clinical and microbiological characteristics of community-acquired and hospital-acquired infections with Staphylococcus lugdunensis in children

Hiroki SAKURAI¹⁾, Yuho HORIKOSHI^1,2)

Staphylococcus lugdunensis is a coagulase-negative staphylococci that mostly presents with low virulence in human diseases. However, it is exceptional in that its virulence resembles Staphylococcus aureus, which can cause invasive diseases. Reports on S. lugdunensis infections in children are still limited both in community-acquired and hospital-acquired infections. The aim of this study was to elucidate clinical and microbiological characteristics of S. lugdunensis in community-acquired and hospital-acquired infections. Cases with isolated S. lugdunensis were included in this study at the Tokyo Metropolitan Children's Medical Center from November 2011 to August 2014. A total of 158 strains were used for analysis. The number of cases with infection and colonization was 14 and 144, respectively. Among those with infection, 6 and 8 cases had community-acquired infection and hospital-acquired infection, respectively. Skin and soft-tissue infection and mediastinitis was common in community-acquired infection and hospital-acquired infection, respectively. Methicillin resistance was observed in 55% of all isolates. There were no methicillin resistant strains in the community-acquired infections, but 62% (5/8) of the strains were methicillin resistant in hospital-acquired infections. In conclusion, S. lugdunensis is an important pathogen that can cause infections in children. This study observed methicillin resistance in hospital-acquired infection.

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1) Division of Infectious Diseases, Department of Pediatrics Tokyo Metropolitan Children's Medical Center
2) Division of Immunology, Department of Pediatrics Tokyo Metropolitan Children's Medical Center

Key words	Staphylococcus lugdunensis, pediatrics, children, community-acquired infection, hospital-acquired infection
Received	August 13, 2018
Accepted	November 2, 2018

31 (1)：21─26,2019