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Article in Japanese

Four cases of human parechovirus-3 infection: An evidence of highly elevated urinary β2 microglobulin levels in the early onset periods

Chieko YAMADA1), Junji AZUMA1), Takeshi ISHIMI1), Motoaki NITTA1), Ryuko AMO1), Mihoko SAKURAI1), Eri KIJIMA1), Keiko NAKATA2), Yoshimi MIZOGUCHI1), Tsunesuke SHIMOTSUJI1), Takehisa YAMAMOTO1)

Human parechovirus-3 (HPeV3) infection is a cause of viral sepsis or central nervous system infection in neonates and young infants, and it could be lethal in more severe cases. Therefore, rapid diagnosis is needed in order to provide effective treatment. This study experienced four cases suffering from HPeV3 infections from 2014 to 2016. Their age ranged from 6 to 43 days. Three of them were treated with intravenous immunoglobulin (IVIG), and the other one with IVIG and intravenous methylprednisolone (IVMP). All of the patients recovered and were discharged without sequelae.
In all of the cases, urinary β2 microglobulin levels increased remarkably in the early stages post onset. However, other inflammation markers such as white blood cell (WBC) counts and serum C-reactive protein (CRP) levels as well as deviation enzymes such as serum aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH) and creatine kinase (CK) levels were within normal ranges.
These results suggested that urinary β2 microglobulin levels might be useful for the diagnosis and estimation of clinical severity of HPeV3 infections.

1) Department of Pediatrics, Minoh City Hospital
2) Osaka Institute of Public Health

Key words urinaryβ2 microglobulin, human parechovirus(HPeV), hypercytokinemia, intravenous immunoglobulin(IVIG)
Received November 27, 2017
Accepted May 22, 2018

30 (3):223─229,2018