Article in Japanese

A 19-year clinical investigation of inpatients with rotavirus gastroenteritis at a community hospital

Satoru TAKASHIMA^1,2), Masaaki YANAI¹⁾

We conducted a retrospective analysis in 1,202 patients who were admitted for rotavirus (RV) gastroenteritis at our hospital between January 1998 and December 2016 to determine the load of the disease and effects of the introduction of its vaccine. The numbers of admitted patients were 68.1, 54.6, and 36.5 per year before (1998-2011), early after (2012-2014), and late after (2015-2016) the introduction of the vaccine, respectively. The rates of decrease in the number of admitted patients were 19.8% and 46.4% per year early and late after the introduction, respectively. The rates of decrease in the number of patients with nosocomial infection were 81.2% and 100% early and late after the introduction, respectively. The median age at admission was 28 months late after the introduction, which was significantly higher than the median of 17 months before the introduction (p < 0.01). Seizure as a neurological complication and intussusception as a gastrointestinal complication were observed in 158 (13.1%) and 8 patients (0.3%), respectively. During the study period, the true-positive rates of RV and adenovirus (ADV) were 2.7% and 21.6% among 291 inpatients with intussusception whom we examined for both fecal RV and ADV antigens, respectively. Between 2014 and 2016, 91.5% of the inpatients with RV gastroenteritis did not receive the RV vaccine.

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1) Department of Pediatrics, Kumamoto Regional Medical Center
2) Department of Pediatrics, Fukuda Hospital

Key words	rotavirus gastroenteritis, rotavirus vaccine, seizure, intussusception
Received	January 18, 2018
Accepted	July 9, 2018

30 (3)：204─211,2018