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The Journal of Pediatric Infectious Diseases and Immunology > Vol.30 No.2 contents > Abstract

Article in Japanese

A case of human parechovirus type 4 infection in a neonate with viral sepsis

Yasufumi TAKESHITA1), Natsumi HASEGAWA1), Kazuyoshi FUKUDA1)

Human parechoviruses (HPeVs) mainly cause mild gastrointestinal or respiratory illness in childhood. While most HPeV types are associated with mild conditions, HPeV type 3 can lead to severe sickness such as meningitis and sepsis-like disease in neonates and young infants. Here, this study describes the case of an 11-day-old girl with viral sepsis due to HPeV type 4 (HPeV-4). The patient was admitted to this hospital with fever, and no other abnormalities were detected in physical examination. Septic workup on admission was unremarkable except for pyuria. She was treated with antibiotics against the fever of unknown origin, but they had no effect on her condition. On day 5 of hospital admission, the laboratory results showed leukocytosis, thrombocytopenia and elevated levels of fibrin degradation products (FDP) and D-dimer. She was diagnosed with "neonatal viral sepsis". Her condition improved after intravenous gamma-globulin treatment. HPeV-4 was detected later from serum and feces by revers transcription-polymerase chain reaction (RT-PCR). HPeV-4 is associated with severe infection in few case reports and it should therefore be considered as a possible cause of sepsis-like disease in neonates.

1) Department of Pediatrics, Saiseikai-Chuwa Hospital

Key words human parechoviruses type 4, sepsis, neonate
Received January 18, 2018
Accepted April 26, 2018

30 (2):153─157,2018