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The Journal of Pediatric Infectious Diseases and Immunology > Vol.30 No.2 contents > Abstract

Article in Japanese

A case of meningitis caused by Streptococcus pneumoniae serotype 15A

Jumpei SUZUKI1), Toshihiko WATANABE1), Hiroyuki SHIMIZU2), Tetsunori FUNABIKI1)

This study reports the case of a 10-month-old boy with pneumococcal meningitis caused by the non-vaccine serotype (NVT), 15A.
Gram-positive cocci (GPC) were detected from the blood and treated with antimicrobial drugs, while otitis media was suspected, and the same GPC was confirmed by adding the cerebrospinal fluid test. Treatment with ceftriaxone and vancomycin was started for suspected pneumococcal meningitis. Afterwards, pneumococci were detected from the blood and cerebrospinal fluid. In addition, the susceptibility test revealed that the pneumococci were resistant to penicillin and meropenem.
Although pneumococcal meningitis has decreased with the introduction of conjugated pneumococcal vaccine, pneumococcal meningitis caused by NVT tends to increase, and meningitis, which is still a severe infection, should not be overlooked. Furthermore, as in this case, attention needs to be paid to detecting the trend of a high resistance rate in serotype 15A to penicillin and meropenem.

1) Department of Pediatrics, Fujisawa City Hospital
2) Department of Infection Prevention and Control, Yokohama City University Medical Center

Key words invasive pneumococcal disease (IPD), penicillin-resistant Streptococcus pneumoniae (PRSP), serotype replacement, serotype 15A, pneumococcal conjugate vaccine (PCV)
Received October 5, 2017
Accepted April 12, 2018

30 (2):127─132,2018