Article in Japanese

A case of Stevens-Johnson syndrome due to acetaminophen

Maki KATO¹⁾, Makoto MORITA¹⁾, Kei IKEDA¹⁾, Michio SUZUKI¹⁾, Shinji HASEGAWA¹⁾

A 7-year-old girl presented with fever, rash on the extremities, and conjunctival hyperemia. Nine days before the symptoms onset, she developed influenza and was given an anti-influenza agent, an antipyretic (acetaminophen), and cold medicine. The next day, she developed skin eruptions and oral enanthema, at which point she came to our hospital and was hospitalized for suspected severe drug eruption. On admission, her skin had areas of erythema and papule on the trunk and extremities, and areas of erosion and vesicles with bleeding on the genital area, oral mucosa and lips. She had difficulty opening her mouth due to severe pain and adhesions of the lips. Her illness was diagnosed as Stevens-Johnson syndrome. Steroid pulse therapy was started, and steroid ointment and eye drops were given after collaboration with a dermatologist and an ophthalmologist. Vesicles on the trunk and the extremities showed crusting, 3 days after administration of steroid, and she gradually became to be able to open her mouth. The patient was cured after one month without ophthalmological sequelae. A drug lymphocyte stimulation test performed after discharge demonstrated a positive result to acetaminophen. HLA analysis revealed HLA class A ^*02:06

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1) Department of Pediatrics, Nagoya Memorial Hospital

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Received	April 13, 2017
Accepted	July 3, 2017

29 (3)：273─280,2017