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Article in Japanese

Neonatal sepsis-like syndrome caused by human parechovirus type 4: A case report

Yumi NAKAYAMA1,2), Yuta AIZAWA2), Taketo OTSUKA2), Akihiko SAITOH2)

A 22-day-old boy presented to our hospital with one day history of fever. Sepsis-like syndrome was diagnosed because of reticular cyanosis in the trunk and limbs. Real-time PCR and a genetic sequence analysis identified human parechovirus type 4 (HPeV4) in his serum. Additionally, serologic testing revealed elevated HPeV4 neutralizing antibody titers, confirming the diagnosis. Among 17HPeV genotypes identified, HPeV type 3 is commonly detected in cases with neonatal sepsis and meningoencephalitis. HPeV4 infection is associated with mild gastroenteritis and respiratory tract infection but only rarely results in sepsis-like syndrome. In contrast, this is the first report of a Japanese patient with sepsis-like syndrome caused by HPeV4. In order to elucidate the clinical features caused by different HPeV genotypes, identification of genotype is necessary and accumulation of cases is important.

1) Department of Pediatrics, Nagaoka Red Cross Hospital
2) Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences

Key words
Received February 2, 2017
Accepted June 29, 2017

29 (3):259─262,2017