Article in Japanese
Disease burden of the pediatric mumps based on the clinical analysis of the hospitalized patients during 2008-2014
Masahiro KAWAGUCH1), Naoko NISHIMURA1), Shuta KITO1), Kazunori HARUTA1), Kei KOZAWA1), Tomoyasu NOGUCHI1), Naozumi FUJISHIRO1), Kensei GOTOH1), Koji TAKEMOTO1), Takao OZAKI1)
This study treated 513 pediatric patients with mumps from April 2008 to March 2014, and 91(18%) of them were hospitalized. The diagnosis of mumps was confirmed serologically in all hospitalized patients, whose age ranged from 1.1 to 14.9 years (median: 5.5 years), with children aged 4-6 years accounting for 53%. The reasons for hospitalization in descending order were 63, 9, 7 and 6 patients with suspected meningitis, febrile convulsions, insufficient oral intake, and suspected pancreatitis, respectively. Swelling of the parotid glands was found in 86 patients (95%), while submandibular gland swelling was observed in 42 (46%). Meningitis occurred in 56 patients (62%) and 1 patient (1%) had orchiditis, but there were no cases of encephalitis, pancreatitis, or hearing loss. None of the patients had a history of mumps.
With regard to prior vaccination for mumps, 83 patients (91%) had not been vaccinated, 7 (8%) had received a single dose, and 1 patient (1%) had unknown history. The 7 vaccinated patients who developed mumps were thought to have secondary vaccine failure based on IgM and IgG antibody titers. Among them, 1 patient developed meningitis. Since a large number of patients with natural mumps require hospitalization, and some vaccinated patients were hospitalized following secondary vaccine failure, it is important to increase the coverage rate of mumps vaccination and introduce a two-dose mumps vaccination schedule.
1) Department of Pediatrics, Konan Kosei Hospital
|Received||January 12, 2017|
|Accepted||July 14, 2017|