Article in Japanese
Candidemia in a Japanese Children's Hospital
Yukitsugu NAKAMURA1), Yuho HORIKOSHI2)
Candidemia is the leading cause of invasive fungal infection in hospitalized patients. To date, few studies of pediatric candidemia have been conducted in Japan. The aim of our study was to investigate the clinical and microbiological characteristics of candidemia in children. Patients showing a positive blood culture for Candida spp. between March 2010 and December 2015 at the Tokyo Metropolitan Children's Medical Center in Japan were enrolled into the study. Patient characteristics and microbiological data were collected from electronic patient records. A total of 24 patients [14 females (58%) and 10 males (42%)] were identified, and their median age was 3 years (IQR 0.4-17 year old). All of the patients had an underlying disease, with the most common being gastrointestinal disease (16/24, 67%). Among these, 12 (12/16, 75%) were short bowel syndrome. A central venous catheter was placed in 22 patients (22/24, 92%). Six Candida species were isolated: Candida albicans (6), Candida parapsilosis (8), Candida glabrata (7), Candida tropicalis (1), Candida krusei (1) and Candida colliculosa (1). Micafungin was administered initially to 54% of the patients, and it generally was susceptible, except for 1 strain of C. glabrata, which posed as FKS mutation. Close monitoring against the emergence of resistance is warranted.
1) Department of Pediatrics, St. Marianna University School of Medicine
2) Division of Infectious Diseases, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center
|Received||November 30, 2016|
|Accepted||March 13, 2017|