Article in Japanese

Presepsin levels in healthy conditioned children

Sorachi SHIMADA¹⁾, Yoichiro YOSHIDA²⁾, Emi ISHIBAZAWA²⁾, Genya TAKETAZU¹⁾, Hiroshi SAKATA¹⁾, Junichi OKI¹⁾

Background; Presepsin (P-SEP), soluble CD 14 subtype, is a free fragment of soluble CD14. In bacterial infection, soluble CD14 is released into serum secondary to monocyte phagocytosis and thus, P-SEP is reported as a useful biomarker for diagnosis or severity assessment of bacterial sepsis. While it is crucial to make an early diagnosis of severe bacterial infection in pediatric patients, traditional biomarkers such as CRP or procalcitonin are not always helpful for early detection of sepsis. There are few reports that discuss the usefulness of P-SEP in children, and its reference range in children is still unknown. Therefore, the aim of this study was to estimate the reference range in healthy children.
Methods: This study enrolled 53 healthy children who visited the outpatient department of this hospital from April 2014 to March 2015 (27 males, aged 0-15 years). P-SEP was measured in plasma samples by chemiluminescent enzyme immunoassay (CLEIA).
Results: The mean level of P-SEP in healthy children was 68.20+/- 26.83 pg/mL. There was no correlation between P-SEP level and sex or age(p=0.244 and 0.776, respectively).
Conclusions: The reference range of P-SEP in healthy children is 68.20+/- 26.83 pg/mL regardless of age and sex.

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1) Department of Pediatrics, Asahikawa-Kosei General Hospital
2) Department of Pediatrics, Asahikawa Medical University

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Received	September 16, 2016
Accepted	March 30, 2017

29 (2)：127─132,2017