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The Journal of Pediatric Infectious Diseases and Immunology > Vol.29 No.1 contents > Abstract

Article in Japanese

A case of croup syndrome requiring intubation caused by human corona virus NL63

Yoko TSURUOKA1,2), Hiroyuki SHIMIZU2,3), Kentaro SHIGA2), Hikari KABA2), Yu FUJIWARA2), Yoshihiro WATANABE2), Saoko TAKESHITA2), Miwako SAIKUSA4), Shuichi ITO5)

A 19-month-old boy showed symptom such as fever and breathing difficulty. He was transferred to Yokohama City University Medical Center due to the potential diagnosis of acute epiglottitis. After admission to the intensive care unit, he was intubated promptly. Conspicuous subglottic swelling was identified under direct vision by a laryngoscope, and his illness was diagnosed as croup syndrome. The patient was administered dexamethasone, furosemide and spironolactone, however any air leak around the endotracheal tube did not appeared. He was intubated for 16 days. Human coronavirus NL63 (HCoV-NL63) genome was detected in the pharyngeal swab specimen, and HCoV-NL63 was determined as the causative organism.
The HCoV-NL63 was isolated for the first time in 2004, and its subsequent association with croup syndrome has been revealed by many studies. It usually causes mild respiratory tract infections in humans, however some infections are serious. Serious croup syndrome with HCoV-NL63, as in this case, has never been reported before. Therefore, more studies are needed to clarify the relationship between HCoV-NL63 and serious croup syndrome.

1) Department of Pediatrics, Yokosuka Kyosai Hospital
2) Children's Medical Center, Yokohama City University Medical Center
3) Department of Infection Prevention and Control, Yokohama City University Medical Center
4) Yokohama City Institute of Health
5) Department of Pediatrics, Yokohama City University, Graduate School of Medicine

Key words
Received September 8, 2016
Accepted February 6, 2017

29 (1):61─66,2017