The Journal of Pediatric Infectious Diseases and lmmunology Online Journal


The Journal of Pediatric Infectious Diseases and Immunology > Vol.28 No.4 contents > Abstract

Article in Japanese

Two children admitted to Sagamihara Kyodo Hospital with familial Mediterranean fever

Kiyotaka OHTANI1), Hitomi INAGAKI1)

Two children presented familial Mediterranean fever (FMF) at Sagamihara Kyodo Hospital. The first was a 7-year-old boy who had experienced repeated fever with abdominal pain every 1-3 months since he was 3 years of age and he presented suspicion of acute abdominal pain with no recognizable symptoms of peritoneal irritation. The C-reactive protein (CRP) level (12.2 mg/dl) had increased, but no organic lesions were detected in any of the imaging inspections. He recovered within 5 days from his first hospital visit. FMF was suspected, and a genetic MEFV analysis identified Ser503Cys/normal on exon 5. As a reaction to colchicine was detected, the patient was diagnosed with FMF. The second patient was an 8-year-old boy who had experienced periodical abdominal pain with occasional fever for a few years. He was treated for constipation after presenting at this hospital. A blood examination showed that this CRP level had not increased, and the findings for collagen and organic disease were negative. FMF was suspected due to his abdominal pain with occasional fever of over 38°C, and a genetic MEFV analysis identified of Leu110Pro/Glu148Gln on exon 2. The patient was diagnosed with FMF due to his reaction to colchicine. Even if a patient repeatedly presents with atypical clinical symptoms, it is important to conduct a genetic MEFV analysis when diagnosing FMF.

1) Department of Pediatrics, Sagamihara Kyodo Hospital

Key words
Received June 30, 2016
Accepted November 28, 2016

28 (4):271─277,2017