Article in Japanese

Interchangeability of genotype C-derived and genotype A-derived hepatitis B vaccines in children

Haruki KOMATSU¹⁾, Shuichiro UMETSU²⁾, Ayano INUI²⁾, Tsuyoshi SOGO²⁾, Tomoo FUJISAWA²⁾

Two hepatitis B (HB) vaccines, i. e. the genotype C-derived HB vaccine (Bimmugen) and genotype A-derived HB vaccine (Heptavax-II), are available in Japan. However, the interchangeability of Bimmugen and Heptavax-II is unclear, and in order to clarify it, 28 children received a series of 3-dose HB vaccine that was evaluated retrospectively. Of the 28 children enrolled in this study, 7 (the two-genotype group, median age: 2 months after birth) received a series of 3-dose genotype C-derived and genotype A-derived HB vaccine. Of the 7 children, 4 received HB vaccines for the prevention of mother-to-child transmission. The remaining 21 children received a series of 3-dose HB vaccine (the single genotype group, genotype A: n=3, genotype C; n=18, median age: 0 month after birth), and 20 of them received HB vaccines for the prevention of mother-to-child transmission. Both groups showed 100 mIU/ml or more of anti-HBs levels after the 3rd shot of HB vaccine. Moreover, there was no statistically significant difference in the levels of serum anti-HBs between the two groups at 1, 6 and 12 months after the 3rd shot of HB vaccine. In addition, there was no breakthrough infection in either group. In conclusion, Bimmugen and Heptavax-II can be interchanged in children.

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1) Department of Pediatrics, Toho University, Sakura Medical Center
2) Department of Pediatric Hepatology and Gastroenterology, Eastern Yokohama Hospital

Key words
Received	April 20, 2016
Accepted	July 20, 2016

28 (3)：179─183,2016