The Journal of Pediatric Infectious Diseases and lmmunology Online Journal


The Journal of Pediatric Infectious Diseases and Immunology > Vol.28 No.3 contents > Abstract

Article in Japanese

Children hospitalized with varicella or herpes zoster in a 6-year period before introduction of routine varicella vaccination

Hiromi HIBINO1), Naoko NISHIMURA1), Masahiro KAWAGUCHI1), Suguru TAKEUCHI1), Hattori FUMIHIKO1), Horiba KAZUHIRO1), Kensei GOTOH1), Haruki HOSONO1), Koji TAKEMOTO1), Takao OZAKI1)

Clinical features were investigated retrospectively in 42 children admitted to this hospital with varicella or herpes zoster infection during the 6-year period before introduction of routine varicella vaccination. Thirty patients with varicella were hospitalized, which accounted for 3% of all varicella patients. Their median age was 3.1 years (28 days-19.0 years) and 93% were≤6 years old. The most common reason for hospitalization was 14 patients (47%) with exacerbated symptoms, and one each with complications of pneumonia and bacterial skin infection. Two children (7%) developed varicella after vaccination, and antibody titers in paired serum samples suggested secondary vaccine failure in both. Twelve patients with herpes zoster were hospitalized. Their median age was 10.1 years (2.0-15.0 years) and the male to female ratio was 1 : 2, thus indicating female predominance. Most of these patients were admitted for fever or pain control, while three (25%) had complications of the central nervous system (meningitis in 2 and facial paralysis in 1). Nine patients (75%) had a history of varicella. Although 2 of the 3 patients with no history of varicella had received vaccination, wild-type VZV DNA was detected in both of them. The trends of hospitalization for these diseases after introducing routine varicella vaccination will be focused on in the future.

1) Department of Pediatrics, Konan Kosei Hospital

Key words
Received March 9, 2016
Accepted June 20, 2016

28 (3):145─151,2016