Article in Japanese

Clinical investigation of hospitalized gastroenteritis patients with adenovirus and rotavirus antigen-positive feces

Fumihiko HATTORI¹⁾, Naoko NISHIMURA¹⁾, Hiromi HIBINO¹⁾, Masahiro KAWAGUCHI¹⁾, Suguru TAKEUCHI¹⁾, Kazuhiro HORIBA¹⁾, Kensei GOTOH¹⁾, Haruki HOSONO¹⁾, Koji TAKEMOTO¹⁾, Takao OZAKI¹⁾

Clinical features were compared between 28 gastroenteritis patients with adenovirus antigen-positive (AdV (+) ) and 178 gastroenteritis patients with rotavirus antigen-positive (RV (+) ) feces who were admitted to our pediatric department between April 2012 and March 2014. Only 2 of the patients with AdV (+) gastroenteritis had been vaccinated for RV. AdV (+) gastroenteritis accounted for 6% of all the patients hospitalized with infectious gastroenteritis (478 patients), and seasonal variation was not observed. RV (+) gastroenteritis accounted for 37% of the patients hospitalized with infectious gastroenteritis, and 92% of the cases (164 patients) occurred from January to May. The age of the patients with AdV (+) gastroenteritis ranged from 3 months to 8 years and 11 months (median: 16 months), whereas that of patients with RV (+) gastroenteritis ranged from 20 days to 14 years and 8 months (median: 23 months). No significant age difference was observed between the two groups. The incidence (%) of major symptoms of AdV (+) gastroenteritis/RV (+) gastroenteritis was as follows: diarrhea 100/100, pyrexia (≥37.5°C) 89/97, vomiting 54/94 (p<0.01), electrolyte abnormalities 25/24, elevated AST or ALT 21/51 (p<0.01), elevated BUN 4/25 (p<0.05), and hypoglycemia 4/11. Four patients with AdV (+) gastroenteritis developed seizures (14%) and 1 had intussusception (4%), whereas seizures occurred in 14 patients with RV (+) gastroenteritis (8%) but intussusception was not observed. Although AdV (+) gastroenteritis was less severe than RV (+) gastroenteritis, complications such as seizures and intussusception require attention.

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1) Department of Pediatrics, Konan Kosei Hospital

Key words
Received	March 30, 2015
Accepted	September 16, 2015

27 (4)：271─278,2016