Article in Japanese

The 7-valent pneumococcal conjugate vaccination reduces the prevalence of pediatric patients with acute otitis media caused by Streptococcus pneumoniae

Meiwa TOYOFUKU¹⁾, Atsuo SATO¹⁾, Hiroyuki SHIRO¹⁾

The objective of this study was to evaluate effectiveness of the 7-valent pneumococcal conjugate vaccine (PCV7) for acute otitis media caused by Streptococcus pneumoniae (S. pneumoniae). This retrospective study investigated the trend of bacterial species detected in the middle ear fluids of children diagnosed with acute otitis media as well as the drug susceptibility of the causative S. pneumoniae strains. A total of 255 isolates were obtained during the study period of between 2007 and 2013 at the author's hospital, and 93 isolates (36%) were identified as S. pneumoniae. The incidence of S. pneumoniae tended to decrease with increasing use of PCV7. S. pneumoniae isolates were detected less frequently in children who had been inoculated with PCV7 than in those who had not (p<0.01). The penicillin resistance rate of the causative S. pneumoniae decreased from 75% in the pre-vaccine era (2007-2010) to 43% in the post-vaccine era (2011-2013). The results of this study demonstrate the prophylactic effect of PCV7 for acute streptococcal otitis media.

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1) Department of Pediatrics, Children's Center, Yokohama Rosai Hospital

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Received	July 8, 2015
Accepted	September 2, 2015

27 (4)：265─270,2016