Article in Japanese

Clinical characteristics of 34 pediatric cases of human parechovirus infection at four hospitals in Japan

Shun KISHIBE¹⁾, Hanako YAMANOUCHI¹⁾, Mihoko ISOGAI²⁾, Masako FUKUSHIMA²⁾, Hiroki SAKURAI²⁾, Shintaro HIROTAKI²⁾, Saeko MORINO³⁾, Kenta ITO^2), Yoshie IWASE⁴⁾, Yoshiaki CHO⁵⁾, Masashi KASAI⁵⁾, Meiwa TOYOFUKU⁷⁾, Yuho HORIKOSHI²⁾

Clinical characteristics of 34 pediatric patients diagnosed with human parechovirus infection were investigated between 2013 and 2014 at four hospitals in Japan. Ninety four percent of the patients (32/34) were less than 3 months of age. Clinical presentations of circulatory failure and central nervous system manifestations were observed in 94% and 68%, respectively. Rash and abdominal distension were observed later in the course in 44% and 21%, respectively. Laboratory findings were generally non-specific at admission. Human parechovirus infection should be included in differential diagnosis of febrile patients aged 3 months or younger who present with circulatory failure and/or central nervous system manifestations.

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1) Department of General Pediatrics, Tokyo Metropolitan Children's Medical Center
2) Department of Infectious Disease, Tokyo Metropolitan Children's Medical Center
3) Infectious Diseases Surveillance Center, National Institute of Infectious Diseases
4) Department of Pediatrics, Sendai City Hospital
5) Department of General Pediatrics, Nagano Children's Hospital
6) Department of Critical Care Medicine, Nagano Children's Hospital
7) Department of Pediatrics, Yokohama

Key words
Received	May 13, 2015
Accepted	September 1, 2015

27 (4)：257─264,2016