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The Journal of Pediatric Infectious Diseases and Immunology > Vol.27 No.3 contents > Abstract

Article in Japanese

Clinical evaluation of doripenem in children

Hiroshi SAKATA

In this multicenter study at 8 pediatric institutions, we retrospectively evaluated the efficacy and safety of doripenem (DRPM) administered to 53 children during the period from February 2013 to May 2014. Among these 53 children, three with off-label use were excluded from the efficacy evaluation. The ages of patients receiving DRPM ranged from four months to 12 years, and the median age was one year. DRPM was administered to 18 patients for less than 3 days and 32 for 3 to 7 days. The diseases were pneumonia in 27 patients, suppurative lymphadenitis in 3, urinary tract infection in 1, and retropharyngeal abscess in 1, respectively. DRPM was clinically effective in all 32 subjects included in the efficacy evaluation. All patients achieved defervescence within 24 hours, over 90% within 12 hours. The effects of DRPM were immediately apparent. Among 53 subjects included in safety evaluation, eight (15.1%) experienced diarrhea but not of sufficient serverity to require the discontinuation of the medication.

Department of Pediatrics, Asahikawa Kosei Hospital

Key words
Received January 13, 2015
Accepted August 20, 2015

27 (3):209─216,2015