The Journal of Pediatric Infectious Diseases and lmmunology Online Journal


The Journal of Pediatric Infectious Diseases and Immunology > Vol.27 No.3 contents > Abstract

Article in Japanese

A case of varicella zoster virus infection with Kawasaki disease-like findings confirmed by a loop-mediated isothermal amplification assay

Fumihiro OCHI1,2), Tetsushi YOSHIKAWA3), Sanae KAWAKAMI1), Kazuyo KUZUME1,2), Hisamichi TAUCHI2), Eiichi ISHII2)

Diagnosis of varicella with typical clinical course or symptoms is easy. However, early diagnosis of patients with non-typical skin findings and a variety of associated symptoms is more difficult. This paper reports a 4-year-old girl with varicella, which was confirmed by a loop-mediated isothermal amplification (LAMP) assay.
She had a fever, right bulbar conjunctival injection, strawberry tongue, edema of the extremities, pale pink erythema on the trunk and extremities, and two vesicles on her finger and wrist. VZV DNA was detected in vesicle swabs using the LAMP assay, thus providing a definitive diagnosis of varicella. On the other hand, VZV-IgM was negative. The early diagnosis of varicella in terms of infection control is very important, and rapid testing by the LAMP assay using a vesicle swab maybe a useful diagnostic tool.

1) Division of Pediatrics, Yawatahama City General Hospital
2) Department of Pediatrics, Ehime University Graduate School of Medicine
3) Department of Pediatrics, Fujita Health University School of Medicine

Key words
Received February 20, 2015
Accepted June 17, 2015

27 (3):183─188,2015