Article in Japanese

A case of acute encephalopathy with biphasic seizures and late reduced diffusion associated with respiratory syncytial virus infection

Yumi SENDA¹⁾, Masahiro MURAOKA^1,2), Mari YAMAMIYA¹⁾, Natsumi INOUE¹⁾, Yukiko KOBA¹⁾, Eri SHINOZAKI¹⁾, Fumie MAEDA¹⁾, Kazunori MIZUNO¹⁾, Mika INOUE¹⁾, Hideaki MAEBA¹⁾, Shinobu SAKAZUME¹⁾, Kazuhide OTA¹⁾, Akihiro YACHIE²⁾, Hisashi KAWASHIMA³⁾

A male case of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) associated with respiratory syncytial virus (RSV) infection was presented. He had fever at the onset, accompanied by convulsions for several minutes. The patient experienced weakness of the left upper extremity, convulsions and disturbance of consciousness on the fourth day of illness. Late diffusion-weighted imaging from a brain MRI showed high intensity in the frontal lobe subcortical white matter. Elevated levels of IL-6 and tau protein within the cerebrospinal fluid suggested the presence of encephalopathy, and dexamethasone and intravenous anti-epileptic medication were introduced. RSV genome was detected by the RT-LAMP method in the cerebrospinal fluid. The patient's left monoplegia protracted, but recovered without sequela.

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1) Department of Pediatrics, Kanazawa Medical Center, National Hospital Organization
2) Department of Pediatrics, Kanazawa University
3) Department of Pediatrics, Tokyo Medical University

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Received	December 2, 2013
Accepted	April 7, 2014

26 (2)：241─246,2014