The Journal of Pediatric Infectious Diseases and lmmunology Online Journal

Abstract

The Journal of Pediatric Infectious Diseases and Immunology > Vol.26 No.1 contents > Abstract

Article in Japanese

Cytokine profile of nasal aspirates obtained from patients with influenza-associated encephalopathy

Soken GO, Yasuyo KASHIWAGI, Hisashi KAWASHIMA, Kouji TAKEKUMA

Although mortality from influenza-associated encephalopathy is lower than before, its sequelae are still high. Therefore, early intervention by treatments is needed. However, diagnosis of early-stage encephalopathy is difficult to predict by conventional laboratory data. Many children with influenza-associated encephalopathy show neurological symptoms of limbic encephalopathy through suspected olfactory bulb. In order to understand the local immune status, this study assayed 17 cytokines and chemokines in the nasal aspirates from 77 patients, who had influenza with (n=4) and without (n=73) encephalopathy. Their cytokine profiles were identical. The levels of G-CSF and CCL4 in patients with encephalopathy were significantly higher than those of patients without encephalopathy. Furthermore, the levels of IL-1β , IL-6 and IL-8 in patients with encephalopathy were higher than those of patients without encephalopathy. The cytokine profiles in their CSF showed similar tendencies. These findings are useful for better predictions of encephalopathy.


Department of Pediatrics, Tokyo Medical University

Key words
Received August 26, 2013
Accepted January 22, 2014

26 (1):21─29,2014

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