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Article in Japanese

Epidemiology about the macrolide resistance of Streptococcus pyogenes in Fukuoka

Yuhei TANAKA1), Mariko TERAMACHI1), Kazuhisa ISHIMOTO1), Kenji GOTOH1), Hidenobu HIDAKA1), Yasushi OHTSU1), Kenji MASUNAGA1), Naoki TSUMURA1), Kensuke NAGAI2), Shizuo SHINDO3)

The aim of this study was to reveal annual changes in antibiotic susceptibility of Group A beta-hemolytic Streptococcus (GAS), especially macrolide in southwestern Japan. The strains of macrolide resistant GAS have been increasing for the last 10 years. Two hundred and eighty six GAS strains were isolated from pharyngitis patients in each period of between 2007 and 2009 (group 1) and 2011 and 2012 (group 2). The MIC and T-type test of these strains were investigated. The rate of erythromycin resistant strains in group 1 was 49.3%, with 24.7% having especially high resistance (MIC≥16μg/ml). In group 2, these rates were 45.8% and 34.1%, respectively. Compared with the author's previous study in 2006, the rate of macrolide resistant rates has increased by approximately 4 times in both groups in this study. The rate of macrolide high resistant strains is increasing yearly, thus suggesting that macrolide resistance of GAS is progressing. Regarding T-serotypes, T-1, T-4, and T-12 were comprised in 62% of group 1. On the other hand, T-1 and T-12 were comprised in 64%, and T-4 in only 3% of group 2. It is likely that a relationship was not seen between T-type and macrolide resistance.

1) Department of Pediatrics, Kurume University
2) Nagai Children's clinic
3) Shindo Children's clinic

Key words
Received December 2, 2013
Accepted January 16, 2014

26 (1):15─20,2014