Article in Japanese

Evaluation of kits for detection of Chlamydophila pneumoniae-specific IgM antibodies

Toshio KISHIMOTO¹⁾, Kazunobu OUCHI²⁾, Kei NUMAZAKI³⁾, Shuji ANDO⁴⁾, Tsutomu YAMAZAKI⁵⁾, Chikara NAKAHAMA⁶⁾

This study evaluated HITAZYME C. pneumoniae Ab-IgM improved by its reducing non-specific reaction with rheumatoid factor and resetting of the serological criteria and anti-C. pneumoniae IgM antibody detection kit made by Ani Labsystems Ltd. The results showed that the HITAZYME C. pneumoniae Ab-IgM kit did not have a non-specific reaction with rheumatoid factor but yielded a possibility of a non-specific reaction caused by other factors. The anti-C. pneumoniae IgM antibody detection kit showed high specificity, as well as low sensitivity, giving the likelihood of producing false-negative results. Thus, we should use these diagnostic test kits in consideration of the improved performance.

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1) Okayama Prefectural Institute for Environmental Science and Public Health
2) Department of Pediatrics, Kawasaki Medical School
3) Division of International Infectious Diseases, Graduate School/Departments of Pediatrics and Infection Control, University Hospital International University of Health and Welfare
4) Department of Virology I, National Institute of Infectious Diseases
5) Department of Pediatrics, Saitama Medical School/Wakaba Children's Clinic
6) Nakahama Cli

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Received	September 13, 2012
Accepted	April 4, 2013

25 (2)：163─168,2013