Article in Japanese

Efficacy of sulfamethoxazole-trimethoprim in the treatment of Haemophilus influenzae meningitis complicated with subarachnoid abscess

Takehiro MORISHITA¹⁾, Keisuke MIZUNO¹⁾, Tomohide TAGUCHI^2,3), Mitsuaki KIMURA²⁾

Case report of a four-month-old infant female with Haemophilus influenzae meningitis complicated with subarachnoid abscess that was treated effectively with sulfamethoxazole-trimethoprim. Treatment with ceftriaxone, meropenem, chloramphenicol and others was ineffective in relieving this infant's symptoms. Finally, treatment with sulfamethoxazole-trimethoprim (S-T) was started because of its excellent ability to penetrate the blood-brain barrier. Following treatment, the condition of the patient including laboratory findings rapidly improved, and she was discharged without any apparent neurological sequelae. S-T should be considered as a treatment option when Haemophilus influenzae meningitis is complicated with subarachnoid abscess.

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1) Department of Pediatrics, Shizuoka Saiseikai General Hospital
2) Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital
3) Presently, Department of Pediatrics Hamamatsu University School of Medicine

Key words
Received	June 15, 2012
Accepted	October 30, 2012

24 (4)：437─442,2013