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Article in Japanese

A case report of vaccine associated paralytic poliomyelitis

Emi ISHIBAZAWA, Fumikatsu NOHARA, Satoshi AMAMIYA, Mayumi KAJINO, Moe AKAHIRA, Masaru SHIRAI, Hiroshi SAKATA, Junichi OKI

We reported a case of vaccine associated paralytic poliomyelitis (VAPP) in a six month old boy. Acute flaccid paralysis developed 21 days after the first administration of oral poliovirus vaccine. The cerebrospinal fluid (CSF) showed a pleocytosis and elevated CSF protein. Nerve conduction velocities were normal. In a T2-weighted image of the spine, the magnetic resonance imaging (MRI) showed high intensity signals in the right anterior horn cells of the twelfth thoracic vertebrae. Vaccine related poliovirus was isolated from his stool samples, neither wild poliovirus nor enterovirus that are implicated in polio like paralytic syndrome were isolated. The residual weakness lasted for more than 60 days after the onset of paralysis. Therefore we diagnosed VAPP. To reduce the risk for VAPP, recommendations for poliovirus vaccination include expanded use of an inactivated poliovirus vaccination.

Department of Pediatrics, Asahikwa Kosei Hospital

Key words
Received June 9, 2011
Accepted October 18, 2011

24 (1):25─29,2012