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Article in Japanese

A case of recurrent meningitis of Streptococcus pneumoniae serotype-6B

Shoji FUKUOKA1), Tadashi HOSHINO1), Chie FUKASAWA1), Jyunpei HASUMI1), Fumie NAGAI2), Katsuaki ABE2), Yoshiko HONDA3), Junko TANAKA3), Haruka HISHIKI3), Naruhiko ISHIWADA3), Yoichi KOHNO3)

We reported on a case of a girl who had recurrent meningitis from Streptococcus pneumoniae serotype-6B at the age of 11 months and 14 months. Multilocus sequence typing analysis revealed the same strain caused each episode of meningitis. Seven-valent pneumococcal conjugate vaccines (PCV7) were administered after recovery from each episode of meningitis. Serotype-specific immunoglobulin G level to 6-B did not rise in spite of the vaccinations. It is suggested that the nasopharyngeal carriage of Streptococcus pneumoniae or invasive pneumococcal disease (IPD) caused serotype-specific hyporesponsiveness to PCV7. Routine immunization of PCV7 should be estimated immediately.

1) Division of Infectious Disease, Chiba Children's Hospital
2) Department of Pediatrics, Chiba Kaihin Municipal Hospital
3) Department of Pediatrics, Chiba University Graduate School of Medicine

Key words
Received May 23, 2011
Accepted July 6, 2011

23 (4):389─393,2012