Article in Japanese

A case of recurrent meningitis of Streptococcus pneumoniae serotype-6B

Shoji FUKUOKA¹⁾, Tadashi HOSHINO¹⁾, Chie FUKASAWA¹⁾, Jyunpei HASUMI¹⁾, Fumie NAGAI²⁾, Katsuaki ABE²⁾, Yoshiko HONDA³⁾, Junko TANAKA³⁾, Haruka HISHIKI³⁾, Naruhiko ISHIWADA³⁾, Yoichi KOHNO³⁾

We reported on a case of a girl who had recurrent meningitis from Streptococcus pneumoniae serotype-6B at the age of 11 months and 14 months. Multilocus sequence typing analysis revealed the same strain caused each episode of meningitis. Seven-valent pneumococcal conjugate vaccines (PCV7) were administered after recovery from each episode of meningitis. Serotype-specific immunoglobulin G level to 6-B did not rise in spite of the vaccinations. It is suggested that the nasopharyngeal carriage of Streptococcus pneumoniae or invasive pneumococcal disease (IPD) caused serotype-specific hyporesponsiveness to PCV7. Routine immunization of PCV7 should be estimated immediately.

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1) Division of Infectious Disease, Chiba Children's Hospital
2) Department of Pediatrics, Chiba Kaihin Municipal Hospital
3) Department of Pediatrics, Chiba University Graduate School of Medicine

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Received	May 23, 2011
Accepted	July 6, 2011

23 (4)：389─393,2012