Article in Japanese

Clinical performance evaluation of Streptococcus pneumoniae antigen detection kit ODK0501 in childhood respiratory tract infections

Satoshi IWATA^1,2), Keita MATSUBARA¹⁾, Naohisa KAWAMURA³⁾, Koichi SHIMIZU³⁾, Kohji AZUMAGAWA⁴⁾, Takao MORINOBU⁵⁾, Shinobu ISHIZAWA⁶⁾, Reiko TAKAYANAGI⁶⁾, Mika NUMATA⁶⁾, Hiroshi UCHIDA⁷⁾, Kumiko SUGITA⁸⁾, Toshio TAKASHIMA⁹⁾, Chikara NAKAHAMA¹⁰⁾, Suguru AKAMATSU¹¹⁾, Keisuke SUNAKAWA¹²⁾

A diagnostic kit (ODK0501) for detecting a Streptococcus pneumoniae (S. pneumoniae) antigen was evaluated using rhinopharyngeal swabs from 105 children with pneumonia or acute bronchitis. ODK0501 has been designed to specifically detect C-polysaccharide (C-ps), a cell wall antigen of S. pneumoniae. Sensitivity, specificity, and concordance rate were 66.0% (33/50), 100% (55/55), and 83.8% (88/105), respectively, demonstrating the usefulness of the kit as a rapid assay for pneumococcal respiratory tract infections in children.

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1) Department of Pediatrics, National Hospital Organization Tokyo Medical Center
2) Center for Infectious Diseases and Infection Control, Keio University School of Medicine
3) Department of Pediatrics, Osaka Rosai Hospital
4) Department of Pediatrics, Seikeikai Hospital
5) Department of Pediatrics, Saiseikai Ibaraki Hospital
6) Department of Pediatrics, Tohoku Rosai Hospital
7) Uchida Children's Clinic
8) Sugita Children Clinic
9) Takashima Shonika Iin

Key words
Received	July 23, 2010
Accepted	September 9, 2010

23 (1)：3─9,2011